Īśāvāsyopaniṣat Bhāshya
Introduction by Acharya Madhva
Īśā.Bhāshya 00
Salutations to the eternal one who sustains the permanent and the impermanent universe, to the embodiment of knowledge, to the one with complete bliss, to lord Hari who is the enjoyer of all sacrifices.

Savayambhu Manu worshipped the divine lord Vishnu by Īshavasya Upanishad mantras, as stated in Brahmānda and Bhāgavata Purāna.
॥hariḥ oṁ॥
Lord Hari is only Ōm!
nityānityajagaddhātre nityāya jñānamūrtaye। pūrṇānandāya haraye sarvayajñabhuje namaḥ ॥1॥
Solutions to the eternal one who sustains the permanent and the non-permanent universe, to the embodiment of knowledge, to the one with complete bliss, to lord Hari who is the enjoyer of all sacrifices.
yasmād brahmendrarudrādidevatānāṁ śriyo'pi ca। jñānasphūrtiḥ sadā tasmai haraye gurave namaḥ ॥2॥
I solute to that lord Hari, who is the inspiration of knowledge to Brahma, Indra, Rudra, and others, and even goddess Shri and also to my Guru.
svāyambhuvo manuḥ etaiḥmantraiḥ bhagavantam ākūtisūnuṁ yajñanāmānaṁ viṣṇuṁ tuṣṭāva।
Savayambhu Manu worshipped the divine lord Vishnu, son of his daughter Ākuti, who also bears the name Yajna by these Upanishad mantras.
svāyambhuvaḥ svadauhitraṁ viṣṇuṁ yajñābhidhaṁ manuḥ। īśāvāsyādibhir mantraiḥ tuṣṭāvāvahitātmanā। rakṣobhirugraiḥ samprāptaḥ khādituṁ mocitastadā। stotraṁ śrutvaiva yajñena tān hatvā'vadhyatāṁ gatān। prādāddhi bhagavān teṣām avadhyatvaṁ haraḥ prabhuḥ। tairvadhyatvaṁ tathā'nyeṣām ataḥ ko'nyo hareḥ prabhuḥ॥
"Manu, the self-existent, worshipped with a concentrated mind, his own daughter son lord Vishnu, known as Yajna, with mantras like the Isha Upanishad. Then, he was approached by fierce demons to devour. Having heard the hymn, the divine Lord granted Manu immortality after killing the demons by the sacrifice. Indeed, it is Lord Shiva, who gave those daemons immortality. Who else other than lord Hari, the master of Lord Shiva can grant mortality to them?"
iti brahmāṇḍe।
- stated thus in Brahmānda Purāna.
bhāgavate ca ayameva artha uktaḥ॥
This very meaning is stated in the Bhagavata Purana as well.

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बहुचित्रजगद्बहुधाकरणात् परशक्तिरनन्तगुणः परमः ।
सुखरूपममुष्य पदं परमं स्मरतस्तु भविष्यति तत्सततम् ॥
"The one who has created this variegated vast universe with varied forms has infinite power and is of infinite auspicious qualities. He certainly bestows the highest state of bliss to those who meditate on his ever happy essence." -Dwādasha stōtra 4.3

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